Receptor Grade IGF-1 LR3 is an altered variant of insulin-like growth factor-1; the complete name of the peptide is insulin-like growth factor-1 long arginine 3. IGF-1 derivatives have played important roles in research studies on cell proliferation, cell division, and cell-to-cell communication. Despite research reporting physiological potential similar to the parent protein, Receptor Grade IGF-1 LR3 does not appear to interact with IGF binding proteins as strongly as IGF-1. Hence, it appears to stay in the bloodstream for longer durations (about 120 times longer) as compared to native IGF-1. The structural modifications in IGF-1 LR3 may have contributed to its increased half-life in the blood. The peptide is created by the inclusion of 13 amino acids to the N-terminus of native IGF-1 and by replacing the glutamic acid at position 3 to arginine.[1]
MOLECULAR FORMULA: C400H625N111O115S9
MOLECULAR WEIGHT: 9117.60 g/mol
SEQUENCE: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
RECEPTOR GRADE IGF-1 LR3 AND CELL DIVISION
Like IGF-1, research suggests that Receptor Grade IGF-1 LR3 may act as a stimulus for cell division and proliferation, primarily affecting connective tissues of the muscle and bone and cell division in the liver, kidney, skin, lung, nerve, and blood tissues. IGF-1 is best considered to be a maturation hormone because of its apparent influence in cell proliferation, differentiation, and maturation, helping them to carry out their specialized functions. The longer life span of Receptor Grade IGF-1 LR3 in the blood makes it a potentially potent molecule as compared to IGF-1. Receptor Grade IGF-1 LR3 appears to provide about three times as much cellular activation compared to similar IGF-1.[2] Researchers report that “The response with LR3IGF-I was particularly striking because this peptide [appears to bind] 3-fold less well than IGF-I to the type 1 IGF receptor.“ It is important to remember that IGF-1 LR3 peptide and every IGF-1 derivative have not been observed to mediate cellular enlargement (hypertrophy), and instead may participate in cell division and proliferation (hyperplasia). For instance, in the case of muscle, studies suggest Receptor Grade IGF-1 LR3 may not induce enlargement of muscle cells, rather simply increasing the total number of muscle cells.
RECEPTOR GRADE IGF-1 LR3 AND MYOSTATIN
Myostatin (also known as growth differentiation factor 8) is a muscle protein that is considered to surpress the growth and differentiation of muscle cells. Myostatin is, thus crucial in protection from unregulated hypertrophy. However, some situations demand inhibition of myosin. Blocking of myosin may be impactful in Duchenne Muscular Dystrophy (DMD) research, or in research related to muscle loss due to prolonged immobility. In such cases, blocking the natural enzyme might slow down muscle breakdown. Studies conducted in mouse models of DMD have suggested that Receptor Grade IGF-1 LR3 and other IGF-1 derivatives may overcome the adverse impacts of Myostatin to protect muscle cells and prevent apoptosis.[3] The scientists note that “results together suggest that myostatin suppresses both basal and IGF-1-stimulated proliferation of both WAT and BAT preadipocytes, actions that are again similar to those in muscle satellite cells”. Receptor Grade IGF-1 LR3, due to its proposed stability, may potentially counteract Myostatin by activating MyoD, a muscle protein normally triggered through prolonged physical strain.
RECEPTOR GRADE IGF-1 LR3 AND METABOLISM, DIABETES
Researchers suggest that Receptor Grade IGF-1 LR3 may indirectly boost fat cell dissolution through association with the IGF-1R receptor and the insulin receptor. These interactions may improve glucose uptake from the blood by muscle, nerve, and liver cells. This potential may result in an overall reduction in blood sugar levels, which then trigger adipose tissue as well as the liver to initiate catabolism of glycogen and triglycerides. Overall, this may lead to a decrease in adipose tissue and net energy consumption (i.e. net catabolism). Given its potential in controlling blood sugar levels, Receptor Grade IGF-1 LR3 may reduce insulin levels and the need for exogenous insulin in diabetes.[4]
RECEPTOR GRADE IGF-1 LR3 AND LONGEVITY RESEARCH
Studies observe that Receptor Grade IGF-1 LR3 may promote tissue repair and cell survival, making it a potentially protective molecule against cellular damage. Research in cows and pigs indicate that Receptor Grade IGF-1 LR3 exposure may possibly overcome the impacts related to cell turnover. Ongoing research in mice has focused on the potential of Receptor Grade IGF-1 LR3 in possibly mitigating the progression of a wide range of conditions such as muscle atrophy, dementia, and kidney disease.[5]
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