PT 141 is an injectable liquid — sometimes delivered as a nasal spray — that some men look to as a potential treatment for ED. In recent years, the FDA approved a version of PT 141 — branded Vyleesi — to treat female hypoactive sexual disorder. No such prescription is available for men. Currently, the only accessible PT 141 outside a Vyleesi prescription comes from scientific research suppliers and is labeled as not suitable for human consumption. As such, we do not recommend its use in men at this time.
PT 141 works as a melanocortin receptor agonist. It binds to receptors in the body typically responsible for control over pigmentation, among other things. One of those other things, it turns out, is erectile performance. It’s also only available in prescription form for women to treat female hypoactive sexual disorder. For men, the only accessible PT 141 comes from scientific research suppliers and is labeled as not suitable for human consumption.
PT 141 gained traction in the early 2000s as a potential treatment for erectile dysfunction while researchers tested potential sunless tanning agents. Regular erections occurred in trials, with the duration of erection increasing along with the dose and consistently outperforming placebos. This led researchers to conclude there was a connection between one of the tanning agents — melanotan II — could function as a treatment for ED.
In the years that followed, researchers isolated bremelanotide — a peptide from melanotan II — that they believed was the primary driver of the erection side effects. This peptide, which is also called PT 141, then entered trials to treat erectile dysfunction. Early trials were mostly successful, but it took nearly 20 years for the drug to gain FDA approval and hit the market in any form. However, Vyleesi, the approved medication, is a form of bremelanotide intended for premenopausal women to treat hypoactive sexual disorder. The FDA has yet to approve a version of the drug to treat ED.
The reasons for this long wait are somewhat unclear, but it may be telling that the company that initially developed PT 141 — King Pharmaceuticals — was acquired by Pfizer in 2010. Pfizer famously manufactures Viagra, and they may have had a vested interest in keeping PT 141 off the shelves until after Viagra’s patent expired in 2020. A close look at the research into PT 141 for sexual function shows a noteworthy gap between 2007 and 2019.
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