Matrixyl is a lipopeptide, combining fatty acids with amino acids. It is also considered a synthetic isomer (an isomer is a molecule with an identical structure to another molecule but different atomic components). The active element in Matrixyl is a second peptide known as Micro-collagen.[1] Researchers report that “The conjugation with the palmitoyl moiety [may] result in more effective delivery across the skin and better stability to skin proteases.”
OTHER KNOWN TITLES: palmitoyl pentapeptide-3
MOLECULAR FORMULA: C39H75N7O10
MOLECULAR WEIGHT: 802.05 g/mol
SEQUENCE: Pal-Lys-Thr-Thr-Ser-OH or Pal-KTTS-OH
Matrixyl appears to combine two matrikines, namely palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. It is a small molecule that is considered to be highly porous in the skin. Structurally, it is similar to collagen precursors. Researchers suggest that the peptide may act to promote the process of repair in the lower layers of damaged skin cell tissues, and has also been termed an “anti-wrinkle” peptide due to the apparent impact it has on wrinkle depth and crease development. It appears to participate in the neosynthesis of extracellular matrix macromolecules.[2] For example, the researchers note that “Delicate balance between the wound healing properties and pro-fibrotic abilities of pentapeptide should be considered for … scar prevention.” In the presence of Matrixyl, the dermal layers may begin to heal themselves, possibly resulting in an acceleration of the natural processes of healing and closure of wounds via cells known as fibroblasts. Fibroblasts appear to gradually lose their capacity for collagen production over time.
Matrixyl was discovered through two independent streams of dermatological research: the search for substances that accelerate repair in damaged skin cells and the exploration of the causes of wrinkle development.[3] Matrixyl appears to act as a signaling molecule that may potentially stimulate collagen and elastin production. Similar to copper peptides, Matrixyl has been suggested to stimulate the lower layers of skin cells to repair damaged tissues in an accelerated manner. Matrixyl appears to stimulate the “matrix” layers in the epidermis – primarily collagen and fibronectin. Cell aging has been divided by researchers into intrinsic and extrinsic types. Intrinsic cell aging occurs via a degenerative process characterized by the loss of collagen. This process results in wrinkling and thinning of the skin and loss of elasticity, and increased stiffness. Matrixyl may signal the extracellular matrix to produce elastin and collagen, potentially combatting cell aging phenomenon.
Researchers have suggested that in the course of study findings, that Matrixyl may potentially induce collagen synthesis by up to 117% over control levels, collagen IV synthesis by up to 327%, and hyaluronic acid synthesis by up to 267%. [4] The researchers also noted that certain synergistic compounds may have contributed to an increase in these finding results.[5]
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
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