CJC-1295 DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) that has the potential to enhance plasma levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).[1] Drug affinity complex (DAC) is an additive component that is considered to prolong the half-life of CJC-1295 in plasma. Researchers have created several synthetic modifications of growth hormone-releasing hormone (GHRH), which appear to retain certain selective traits of the hormone while eliminating others. CJC-1295 happens to be one of such synthetic analogs that comprise the first 29 amino acids of GHRH. Interestingly, it happens to be a maleimide derivative of 1-29 residues of hGRF. This may help produce a GH secretagogue with greater solubility, which may be easier to synthesize in larger volumes.
CJC-1295 DAC shares similarities with other GHRH analogs like Sermorelin, as both are derivatives of the first 29 amino acids of GHRH. It is also closest to, but not identical, to Modified GRF (1-29). The similarity and the fact that CJC-1295 was created along with DAC creates confusion between the peptides. Through a lysine linker, DAC is attached to CJC-1295 with the intention to protect the peptide during its circulation in the bloodstream. DAC appears to facilitate the association of peptides with blood proteins such as albumin. This appears to enhance their half-life compared to similar peptides such as GRF (1-29).[2]
OTHER KNOWN TITLES: CJC-1295 with DAC
MOLECULAR FORMULA: C152H252N44O42
MOLECULAR WEIGHT: 3647.954 g/mol
SEQUENCE: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Mal)-NH2
CJC-1295 DAC AND GROWTH HORMONE RELEASE
The peptide was developed with the intention to trigger the release of growth hormone (GH), as it is a synthetic analog for the natural GHRH. Mice model experiments have reported that a single exposure to the peptide may induce almost 2-10 times higher production of GH.[3] GH expression appears to reach a maximum level after 2 hours of peptide introduction, and the action appears to be maintained up to about six days later. The peptide appears to maintain the natural physiological level of GH, unlike other secretagogues. In other words, CJC-1295 has the potential to perform as a physiological GHRH and maintain the natural biological high and low expression pattern in GH levels. CJC-1295 appears to maintain the physiological level of the hormone while enhancing its release in the blood. CJC-1295 has been studied in relation to physiological regulation of GH on protein synthesis, fat metabolism, blood sugar, hypertrophy, bone density, hyperplasia, and myocardial function.
CJC-1295 DAC AND INFERTILITY
Studies from the early 1990s suggest that CJC-1295 and other GRF analogs may improve female infertility. Mice models of superovulation have suggested that GH and IGF-1 levels increase in blood around the time of ovulation.[4] Thus exposure to CJC-1295 and GRF analogs may promote ovulation in female animals, possibly through IGF-1 and GH expression cycle. The exposure of GH secretagogues like CJC-1295 may be sufficient to promote ovulation. Scientists have further suggested these analogs may improve sperm production, though research is inconclusive.
CJC-1295 DAC AND GROWTH
Research has suggested that CJC-1295 may restore the physiological release of GH in mice lacking normal GH physiology.[5] Jette et al. notes that “CJC-1295, showed a 4-fold increase in GH area under the curve over a 2-h period.” The peptide may potentially be researched in the context of growth anomalies in different mammalian species. Maintenance of the circadian cycle of GH release appears to be crucial to bringing about appropriate production of downstream hormones, such as insulin-like growth factor-1 (IGF-1).
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
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