• Bremelanotide PT-141 10mg/ vial
  • Bremelanotide PT-141 10mg/ vial

Bremelanotide PT-141 10mg/ vial

buy pt 141 online with high quality for sale
  • Bremelanotide PT-141 10mg/ vial

What is the PT-141 Peptide?

PT-141, also known as bremelanotide, has been investigated in phase IIb human clinical trials to treat female hypoactive sexual desire disorder (HSDD). It was derived from a synthetic Melanocortin known as Melanotan 2 (MT-2). PT-141 is a Melanocortin that  was developed to interact with Melanocortin-4 Receptor (MC-4R) and MC-1R. PT-141 has been studied for a variety of potential benefits, including implications in sexual dysfunction and cancer, and in aiding hemorrhages.


AKA: Bremelanotide


MOLECULAR WEIGHT: 1025.2 g/mol

SEQUENCE: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH

PUBCHEM: CID 9941379

CAS NUMBER: 189691-06-3


PT-141 Research

PT-141 appears to uniquely stimulate the MC-4R, which may trigger sexual arousal in the central nervous system and can affect sexual behavior.[1] The researchers report that “The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base.” Studies in mice agonist binding to MC-4R reported sexual arousal and enhanced copulation in both males and females.[2] The mechanism of PT-141 is different from medications like Viagra; it has the potential to treat both male and female sexual arousal disorders that are not caused by reduced blood flow to the genitals. One-third of men who suffered from erectile dysfunction (ED) but did not respond to sildenafil (Viagra) appeared to experience satisfactory erection for sexual intercourse using PT-141 (administered via nasal spray). The strong dose-dependent response in the trial indicated the effectiveness of PT-141 in some cases.  Interestingly, it was removed from clinical trials for treating women with HSDD despite showing increased female sexual satisfaction and reducing female sexual distress scores without side effects.[3] Experts on female sexual dysfunction (FSD) consider a lack of established endpoints for trials of FSD and socio-cultural biases against women’s sexual health as the essential reasons for the  non-approval of PT-141.[4] Researchers suggest the PT-141 treatment if combined with other existing modalities may enhance both physiological and psychological efficacies. In 2017, partly due to the outcry against the cessation of earlier trials, Phase II Reconnect trials were initiated for PT-141 for FSD, and research reporting is ongoing.

The MC-1R appears to mediate important anti-fungal and anti-inflammatory effects in a rat model of specific fungal infection.[5] This may be relevant to PT-141 peptides as current medications have limited mechanisms of action and show adverse effects in some patients. The alternative therapy might control morbidity and mortality, especially in immunocompromised patients.

In 2009, modified PT-141 was investigated for use in hemorrhagic shock. The peptide appears to control ischemia and protect tissues against inadequate blood supply hypovolemic (hemorrhagic) shock through interaction with both MC-1R and MC-4R. It was observed in phase IIb trials that the administration of the peptide exhibited no side effects. The modified version is referred to as PL-6983.

The MC-1R receptor may be an important stimulus of DNA repair pathways, and is of relevance in cancer research and prevention.[6] The scientists reported that “MC1R signalling activates antioxidant, DNA repair and survival pathways.” People with variants of MC-1R appear to be more prone to both basal cell and squamous cell carcinoma.[7] Altered PT-141 may be used to bind to these variants and prevent or treat these cancers.

Direction of Future Studies for PT-141 Peptide

Right now, PT-141 is well known for its potential in sexual dysfunction research. There is potential to expand its research in other diseases. For instance, a mutant or deleted MC-4R may trigger some instances of obesity and influence about 6% of early-onset obesity cases. PT-141 may help to study this specific reason for obesity and illustrate a pathway for intervention. MC-1R has also been associated with pain, inflammation, kidney pathology, and the spread of infection; the peptide may help investigate diverse research domains. Experimental research in PT-141 reports the peptides appears to exhibit minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage (per kg) in mice does not match humans.

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