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Jan.2024 04
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How MGF works:MECHANO GROWTH FACTOR
Introduction
The Mechano Growth Factor (MGF), a member of the IGF-1 superfamily, exhibits exercise and age-dependent expression. The MGF-24aa-E peptide demonstrates the potential to enhance satellite cell activation, proliferation, and fusion for muscle repair, particularly in neonatal and young adult muscle, offering a promising strategy to address age-related sarcopenia without the observed oncogenic side effects associated with IGF-1.
Details

MECHANO GROWTH FACTOR

Mechano Growth Factor, commonly known as MGF, is a peptide derived from a distinct sequence of insulin-like growth factor-1 (IGF-1), a key player in childhood development with ongoing anabolic effects in adulthood. Triggered by the stretching and exertion of muscles, MGF is notably abundant after intense weight training sessions.

The unique property of MGF lies in its capacity to stimulate the repair and growth of depleted tissue by activating muscle stem cells, thereby enhancing the synthesis of proteins essential for tissue development. This peptide proves particularly beneficial for individuals experiencing muscle loss, whether due to aging or specific health conditions.
Benefits of MGF:

Stimulating the activation of muscle satellite stem cells, Mechano Growth Factor (MGF) plays a pivotal role in initiating the fusion of these 'satellite' cells with existing muscle fibers. This fusion process is crucial as it provides the additional nuclei necessary for effective repair. In essence, MGF becomes essential for facilitating the recovery, repair, and growth of new cells, contributing significantly to overall muscle development and resilience.


How MGF works:

IGF-I undergoes splicing towards Mechano Growth Factor (MGF), a crucial element in initiating muscle hypertrophy and repairing localized muscle damage. MGF expression is triggered by mechanically overloaded muscles, playing a key role in tissue repair and adaptation. Following muscle damage, MGF is expressed in pulses, actively engaging muscle satellite (stem) cells to donate nuclei essential for repair and the hypertrophy process.

Similar to IGF-1, MGF is indispensable for cellular repair and subsequent growth. Notably, if MGF is not PEGylated, its half-life is only several minutes. Therefore, the compounding process should involve PEGylation of MGF to ensure an appropriate half-life, ultimately extending its duration of action in promoting muscle recovery and adaptation.

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