AOD 9604 is a modified peptide initially developed as an offshoot in obesity research. It modifies the peptide fragment 176-191 of the growth hormone HGH by adding a tyrosine residue to the N-terminus. The proposed mode of action of AOD 9604 has been suggested by researchers to be restricted to promoting lipolysis, thus linking the synthetic compound to obesity research.[1] The peptide does not appear to affect levels of insulin or IGF1 in studies thus far; therefore, it may not trigger diabetes development or induce glucose intolerance in test models, though further studies are necessary to explore this aspect.[2]
OTHER KNOWN TITLES: AOD-9604
MOLECULAR FORMULA: C78H123N23O23S2
MOLECULAR WEIGHT: 1815.1 g/mol
SEQUENCE: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
PUBCHEM: CID 16131447
CAS NUMBER: 386264-39-7
RECONSTITUTION: Required
AOD 9604 STRUCTURE
Scientists hypothesize that different parts of the HGH molecule may possess different properties and induce different effects in test models.[3] It has been suggested that only the last 15 amino acids may mediate any fat-burning potential of the hormone. The fragment was initially named HGH 177-191 and was subsequently modified by adding tyrosine to create AOD 9401, potentially to help stabilize the molecule. This modification led to the production of a 16-amino acid fragment called AOD 9604.[4] Interestingly, the researchers comment, “AOD 9604 does not interact with the hGH receptor.” This modification may have made the HGH frag 176-191 relatively more stable than other peptides.
AOD 9604 MECHANISM OF ACTION
AOD 9604 has mainly been studied in murine models, and significant experiments have involved relatively large amounts of AOD 9604 in a murine model.[5] These experiments reportedly resulted in a 50% reduction in weight. However, it is important to note that the fragment appears to lack any other potential effects of HGH, such as increasing IGF-1 (insulin-like growth factor-1), insulin resistance, or cell proliferation. Therefore, the compound may not possess the potential muscle-preserving and anabolic effects typically associated with growth hormones. Nevertheless, it appears that AOD 9604 may stimulate weight loss through mechanisms similar to HGH, as it may trigger various cellular pathways that might lead to the release of fatty acids from adipose cells. Additionally, researchers have posited that the peptide may affect the activity of lipases, a group of enzymes that prevent the return of fat to adipose tissues.[6] It is worth noting that AOD 9604 does not appear to affect natural HGH production and does not appear to act as a growth hormone secretagogue. Moreover, it does not appear to impact hunger levels or increase appetite. Murine models comparing AOD 9604 and HGH have reported different outcomes in lean and obese cases.[4] In lean murine models, HGH appears to increase lean body mass, whereas AOD 9604 or a placebo did not appear to produce the same action. Hence, researchers have speculated that HGH AOD 9604 may not be effective in increasing the size of muscle cells and contributing to muscle hypertrophy. However, in obese murine models, both HGH and AOD 9604 appear to exert a weight loss potential. The scientists also commented that there was an apparent 40% reduction in adipose tissue in the HGH group compared to 28% with AOD 9604. Therefore, experiments suggest that AOD 9604 may hold reduced potential compared to HGH in stimulating the release of fats from adipose cells.[7] The researchers also posit that “the lipolytic actions of both hGH and AOD 9604 are not mediated directly through the β3-AR although both compounds increase β3-AR expression, which may subsequently contribute to enhanced lipolytic sensitivity.” Growth hormone likely promotes a greater release of fats from adipose cells due to its proposed impact on insulin resistance. By reducing glucose uptake, it may force cells to potentially utilize more fat instead. In contrast, the fragment AOD 9604 does not appear to potentially increase insulin resistance. Additionally, anecdotal data suggests that AOD 9604 may potentially offer some benefits, including modest improvements in cholesterol levels and insulin sensitivity, but it is yet to be confirmed by murine models.
AOD 9604 AND OBESITY
AOD 9604 has been brought into clinical trials with the objective of targeting obesity using a peptide similar to HGH. Phase 2b clinical trials conducted on 300 obese test subjects in Australia observed that the peptide appeared to result in consistent weight loss over 12 weeks when introduced once daily.[8] The rate of weight reduction in test subjects was consistently compared to the placebo cohort, and weight loss appeared to hold steady over the entire study period. This observation indicated that the peptide is unlikely to generate resistance, and thus continued influence of the peptide might result in a pronounced effect. Study in this area is ongoing.
Researchers have also utilized mice models to explore the underlying mechanism of AOD 9604. An initial hypothesis proposed that AOD 9604 may bind and activate β-3-adrenergic receptors, which are present on the surface of white adipose tissues. Upon binding to the cognate receptors, the peptide may trigger downstream signaling, which would mobilize the fat cells from storage mode to a usable state by enhancing the rate of metabolism. Interestingly, mice genetically mutated in β-3-adrenergic receptors underwent fat loss, possibly through apoptosis of the white adipose tissues.
AOD 9604 AND CARDIAC DISEASE
AOD 9604 may host the potential to improve cardiac health indirectly by mobilizing fat and reducing obesity. The peptide may reduce the chances of cardiac disease caused by obesity as a natural consequence. Apart from its proposed principal function of decreasing fat burden, research teams have suggested other mechanisms by which the peptide might improve cardiac conditions. These pathways are independent of β-3-adrenergic receptors and appear to improve general metabolism, improving cardiac health.[9]
JOINT PAIN AND FUNCTION
Research suggests that AOD 9604 influence in the arthritic joints in rabbits may have contributed to an improvement in pain management and decreased movement disability.[10] Researchers have speculated that AOD 9604 may promote the growth of cartilage tissue in the arthritic joints but have yet to fully investigate this hypothesis. Experimental examination and microscopic cartilage structure analysis in affected joints have indicated positive results upon AOD 9604 influence in osteoarthritis test subjects.
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Applications：
Many pro athletes in every sports use it
1) Muscle tissue growth 2) A leaner & tighter physique
3) Enhanced bone, joint & tendon strength 4) Faster recovery
5) Improved cholesterol levels 6) Increased endurance and performance in the gym
7) Higher energy levels 8) Increased libido
9) Improvements in the Immune system 10) Improvements in skin - smoother skin
11) Increased metabolism 12) Increased fat loss
13) Deeper sleep
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Q: Is there a discount?
A: Yes, for larger quantity, we always support with better price.
Q:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
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