PT-141, also known as Bremelanotide, was derived from a synthetic Melanocortin known as Melanotan 2 (MT-2). PT-141 is a Melanocortin that was developed to interact with Melanocortin-4 Receptor (MC-4R) and MC-1R. PT-141 has been studied for a variety of potential characteristics and bioactiviies, including implications in sexual dysfunction and cancer, and aiding hemorrhages.
OTHER KNOWN TITLES: Bremelanotide
MOLECULAR FORMULA: C50H68N14O10
MOLECULAR WEIGHT: 1025.2 g/mol
SEQUENCE: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH
PT-141 PEPTIDE (BREMELANOTIDE) AND AROUSAL
PT-141 appears to uniquely stimulate the MC-4R, which may trigger cascades in the central nervous system which impact the brain region that controls sexual behavior.[1] The researchers suggest that “The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in [cases that otherwise] do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative [avenue for ED research].” Studies in mice agonist binding to MC-4R reported sexual arousal and increased copulation activity in both males and females.[2] The mechanism of PT-141 appears to be different from compounds that manage blood flow to the genitals.[3][4] Researchers suggest that PT-141, potentially combined with existing modalities, may encourage both physiological and psychological alterations.
PT-141 PEPTIDE (BREMELANOTIDE) AND INFECTION
The MC-1R appears to mediate important anti-fungal and anti-inflammatory effects, as seen in one study using a rat model of specific fungal infection.[5] This may be relevant to PT-141 peptides as current compounds have limited mechanisms of action and may exhibit adverse effects in some cases. The alternative in PT-141 might impact morbidity and mortality, especially in immunocompromised cases.
PT-141 PEPTIDE (BREMELANOTIDE) AND HEMORRHAGE
In 2009, modified PT-141 was investigated for use in hemorrhagic shock. The peptide appears to control ischemia and protect tissues against inadequate blood supply hypovolemic (hemorrhagic) shock through interaction with both MC-1R and MC-4R. The modified version is referred to as PL-6983.
PT-141 PEPTIDE (BREMELANOTIDE) AND CANCER CELLS
The MC-1R receptor may be an important stimulus of DNA repair pathways, and is of relevance in cancer cell research.[6] The scientists reported that “MC1R signalling activates antioxidant, DNA repair and survival pathways.” Research models of variant MC-1R receptors appeared to be more prone to both basal cell and squamous cell carcinoma.[7] Altered PT-141 was suggested to be efficacious in these cases.
Whatever you're looking for, we've got it!"Ready to explore further?
Inquiry directly for more details
About us
WuhanZhengtai Technology Co., Ltd is mainly engaged in the export of fine chemicals, cosmetic raw materials, food additives, pharmaceutical intermediates and other products; Our company is committed to the development of international market, our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
Meanwhile, we possess of complete Q. A. And Q. C. System, supply chemical products with good quality and custom-tailored products according to our clients′ requirement. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the 15 years. With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
Our advantages
Quality: Purity above 99%, directly produced by the manufacturer, can accept quality testing, and can also customize any content of powder, liquid, oil, etc.
Transport: We can accept sea freight, air freight, and express delivery, with a guarantee time of 1-2 weeks and a customs clearance rate of over 99%.
Service: In addition to powder, we also have liquids, water-based agents, oils, tablets, and professional customized synthesis routes. We provide you with professional guidance on product use, product synthesis, and product customization.
Price: We do not engage in price wars. We are manufacturer and can provide high quality products with factory price.
RFQ
Q: How to start orders or make payments?
A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How to confirm the Product Quality before placing orders?
A:You can get samples for some products to test. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q: What's your MOQ?
A:For the high value product, our MOQ starts from 1box.
Q: Is there a discount?
A: Yes, for larger quantity, we always support with better price.
Q:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q:How to contact us ?
You can choose your interested products and send inquiry to us.You can dial our telephone directly.
