HEXARELIN (also known as Examorelin) is a synthetic analog of ghrelin and shares a high degree of structural similarity to GHRP-6. The only difference between Hexarelin and GHRP-6 is the inclusion of two methyl groups in the structure of GHRP-6. Like other ghrelin analogs, this peptide is reported by researchers to display high selectivity in its mode of action.[1] It has been extensively studied in relation to cardiac cell survival after ischemia and nutrient deprivation.
MOLECULAR FORMULA: C47H58N12O6
MOLECULAR WEIGHT: 887.05 g/mol
SEQUENCE: His-2-Me-D-Trp-Ala-Trp-D-Phe-Lys-NH2
HEXARELIN AND MUSCLE CELL PROTECTION
The peptide has been suggested to protect muscle cells in and outside of the heart. Studies in Hexarelin and GHRP-6 observe how the peptides may control calcium flow and mitochondrial dysfunction in muscles of rats suffering from cachexia (extreme weight loss due to illness or chemotherapy).[2] The researchers report that the secretagogue may potentially “protect skeletal muscle from mitochondrial damage and improve lean mass recovery.” It also appears to keep muscle cells viable by maintaining mitochondrial integrity. Through its energy supply, Mitochondria help muscles carry out day-to-day functions. It has been suggested that calcium ion regulation is often disturbed due to chemotherapy and may be one of the principal causes for any altered muscle and lean body mass. Researchers suggest the potential for Hexarelin and GHRP-6 to potentially support the reestablishment of proper calcium regulation.
HEXARELIN AND CARDIAC FUNCTIONS
Hexarelin appears to affect the heart through its association with the CD36 receptor and the growth hormone secretagogue receptor (GHSR). Research conducted on murine models suggest that the peptide appears to protect cardiac cells from injury in the backdrop of cardiac arrest.[3] The scientists even note that Hexarelin “may be a promising [research] agent for some cardiovascular conditions.” Researchers suggest that the peptide may interact with the aforesaid receptors and prevents apoptosis of the cardiac cells. The peptide may help improve cardiac function, increasing the number of surviving cardiac cells and reducing the levels of malondialdehyde (cardiac cell death marker). Interestingly, the study also suggested GHRP-6 to be partially superior in function compared to ghrelin. Hexarelin has also been observed to ameliorate oxidative stress in cardiac cells during cardiac failure as well as to prevent myocardial remodeling in rats.[4] Cardiac remodeling causes a decrease in cardiac function and can be fatal. However, GHRP-6 or Hexarelin-exposed rats appeared to show significant improvement in their cardiac function compared to the controls. The molecular mechanisms underlying the function of the peptide have been suggested to involve an increase of phosphatase and tension homologue (PTEN) activity and subsequent reduction in protein kinase B levels. While PTEN is considered to regulate cellular regeneration, protein kinase B appears to help modulate cell survival. GHRP-6 and Hexaralin may mediate cardiac remodeling by switching the nervous system response from sympathetic (includes increased blood pressure, heart rate, etc.) to parasympathetic. This regulation may help to improve short-term function. Moreover, when exposed to the peptide following cardiac arrest, studies with rat models observed a significant decrease in scar tissue arising from cardiac tissue healing. The peptide may have the potential for assisting in numerous cardiac damages as its mode of action is not hypothesized to be specific to protection against heart attack. Studies in rat models of diabetes have also observed Hexarelin to potentially improve cardiac function by altering the processing of calcium and potassium by cardiac muscle cells.[5]
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