Gonadorelin (GnRH) is a decapeptide gonadotropin-releasing hormone agonist.[1] It appears to work by stimulating the synthesis and release of luteinizing hormone and follicle-stimulating hormone. It is being researched within the context of infertility and reproductive systems, and hypogonadism. It is also studied for its potential as a diagnostic tool to assess pituitary function.[2]
OTHER KNOWN TITLES: Growth Hormone Releasing Factor, Somatocrinin, Somatoliberin
SEQUENCE: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
MOLECULAR FORMULA: C55H75N17O13
MOLECULAR WEIGHT: 1182.311 g/mol
GONADORELIN RESEARCH AND BREAST CANCER
Research studies in Gonadorelin and ovarian cancer have suggested that the peptide may exhibit the potential to mitigate the onset of certain cancers via estrogen production regulation.[3] Scientists report that “Fusion of GnRH to hpRNase1 structure produced an enzyme, which could specifically target tumor cells.” [4] Prolonged studies in animal research models of breast cancer have suggested exposure to Gonadorelin may reduce risk of cancer cell proliferation by up to 70%, depending on duration.[5] Studies have also suggested that estrogen-inhibiting measures may reduce disease progression by 50% if the cancer is estrogen-sensitive. Cancer cells are considered to develop resistance over time, usually resulting from increased expression of estrogen receptors. Gonadorelin may directly reduce the growth of estrogen-sensitive cancers and increase receptor efficacy, as posited by researchers.[6] Studies in research models of hyperandrogenism have suggested further that long-term GnRH exposure may lower total estrogen levels and reduce the risk of breast cancer cell growth and proliferation. [7]
GONADORELIN AND PROSTATE CANCER
Exposure to GnRH in research models of prostate cancer began in 1979. Researchers observed that some androgens are formed locally in the prostate through a mechanism called intracrinology.[8] The posited that GnRH acted as a blockade, and appeared only partially effective in mitigating prostate cancer cell growth and proliferation.
GONADORELIN AND DEMENTIA
Scientists consider that Luteinizing Hormone (LH), may act on the brain in ways beyond what is typically associated with the hormone, such as sexual dimorphism and fertility. Indeed, increased LH levels have been suggested to hold a positive correlation with incidences of Alzheimer’s disease and reduced memory capacity. Rats exposed to greater LH levels exhibited poor memory and hippocampal dysfunction. This was a defect that was apparently remedied by the influence of LH blockers.[10] Further research on LH observe that higher hormone levels are associated with increased neuropathology. In particular, LH has been suggested to promote the formation of plaques associated with Alzheimer’s disease.[11] The researchers conclude that “Reducing the LH levels by treatment with gonadotropin-releasing hormone agonists could provide [numerous] benefits.” Therefore, researchers assume that lowering LH levels may help slow the progression of Alzheimer’s disease. Testosterone is considered beneficial for maintaining cognitive function. Therefore, blocking the entire hypothalamus-pituitary-gondola axis may not always be recommended for mitigating Alzheimer’s disease. For this reason, scientists have sought to test Gonadorelin derivatives to see if selective disruption of LH production is possible.[12] One ongoing study suggests that Leuprolide, a common substance used with uterine fibroids and GnRH receptor agonists, has been suggested by researchers to potentially reduce the risk of Alzheimer’s disease compared to other Gonadotropin analogs. In this situation, Leuprolide may possibly offset the risk of CAB for Alzheimer’s disease. In particular, researchers studied the apparent ability of Leuprolide to downregulate serum gonadotropin levels (especially LH) and found it generally sufficient to offset the effects of decreased testosterone.[13] Researchers are currently working to understand how the genetic interactions of Alzheimer’s disease may be disrupted. Gonadorelin is an important peptide in this study.
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