GHRP-2, also known as pralmorelin (also available in 10mg) is a synthetic growth hormone secretagogue which interacts with the ghrelin/growth hormone secretagogue receptor. It is a research peptide studied to evaluate growth hormone deficiency as well as secondary adrenal failure. Extensive research has also been performed to evaluate its role in the regulation of muscle development, appetite, the immune system, and sleep cycles.[1]
OTHER KNOWN TITLES: Thymosin Beta 4
MOLECULAR FORMULA: C45H55N9O6
MOLECULAR WEIGHT: 817.9 g/mol
SEQUENCE: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
GHRP-2 AND MUSCLE STRUCTURE
Research in yaks noted that GHRP-2 peptide appeared to stimulate the growth of muscles in two ways: enhanced protein synthesis and accumulation, and reduced protein degradation.[3] The study suggested that GHRP-2 may help to overcome natural growth limitation that occurs in yaks because of food deprivation, adverse environmental conditions, and disease. The researchers also posited that “GHRP-2 enhanced muscle protein deposition mainly by up-regulating the protein synthesis pathways.” The most significant observation has been the potential action of GHRP-2 in reducing muscle atrophy through repression of atrogin-1 and MuRF1- proteins, which regulate muscle degradation pathways.
GHRP-2 AND THE HEART
Studies in fetal heart cell culture lines have theorized that GHRP-2 and its analogs (GHRP-1 and GHRP-6) may help to protect cardiac cells by minimizing apoptosis or programmed cell death.[4] The peptide appears to protect cardiac muscles from reduced supply of blood and nutrients, which may ensue a cardiac arrest. Studies on Hexarelin, a GHRP-2 analog, have posited that these peptides associate with a specific receptor.
GHRP-2 AND THE IMMUNE SYSTEM
GHRP-2 peptide researchers suggest the peptide may enhance the functions of the thymus, an organ that helps protect and mature certain cells of the immune system, especially the T lymphocytes.[5] T lymphocytes are crucial for adaptive immunity and the physiological capacity to combat complex infections. However, the efficacy of the thymus diminishes, which may induce instances of tissue damage, to diminished immunity. In such cases, GHRP-2 appears to have the potential to rejuvenate the thymus, possibly promoting the number and diversity of T-cells, possibly boosting general immunity.
GHRP-2 AND PAIN PERCEPTION
Researchers initially hypothesized that GHRP-2 may decrease pain associated with osteoarthritis in animal models through the stimulation of growth hormone production and the repair of damaged tissues. However, it has been suggested since that GHRP-2 may induce pain relief prior to tissue repair, which may occur due to an action on opioid receptors. There are four known opioid receptors.[6] Other compounds studied for their impact on opioid receptors appear to typically mediate a universal action on all four receptors. The generic mode of action may create challenges as the receptors may have differential and diverse functions. GHRP-2 appears to be a selective opioid receptor agonist, binding uniquely to the receptors implicated in pain perception, reward system linking, and sedation.
GHRP-2 AND SLEEP CYCLES
GHRP-2 has been suggested to influence sleep cycles. The peptide may increase the duration of stages 3 and 4 of the sleep cycles by up to 50%, as reported by researchers, as well as potentially improve the duration of REM sleep by approximately 20%.[7] It may further diminish deviation in sleeping patterns from “normal sleep”. Research is ongoing.
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