Studies have suggested that a maximal output of endogenous growth hormone (GH) from the anterior pituitary gland might be attained through a combination of growth hormone-releasing hormone (GHRH) analog and agonist of growth hormone secretagogue receptor (GHSR).[1] The combination of Ipamorelin with Modified GRF is one of the various combinations researchers have studied in an effort to achieve maximal growth hormone production. Interestingly, more specific results appear to be achieved beyond the increase in GH synthesis through the refinement of the choice of GHRH analog, and GHSR agonist used. Modified GRF, which researchers have suggested may be an effective GHRH analog, may have impacts beyond GH release. It has appeared to impact intestinal inflammation, tissue repair, and cardiac function in animal models. Ipamorelin has the potential to improve bone growth and stabilization of the cellular matrix. The above physiological outcomes are in addition to the potential for improvement of bone development via increased GH release.
MOLECULAR FORMULA: C78H125N23O23S2
MOLECULAR WEIGHT: 1817.1 g/mol
SEQUENCE: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
MOLECULAR FORMULA: C152H252N44O42
MOLECULAR WEIGHT: 3367.95 g/mol
SEQUENCE: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
MOLECULAR FORMULA: C38H49N9O5
MOLECULAR WEIGHT: 711.85 g/mol
SEQUENCE: Aib-His-D-2Nal-D-Phe-Lys-NH2
FRAG 176-191 & MOD GRF 1-29 & IPAMORELIN AND BODY MASS
Researchers hope to find potential in these peptides to promote fat cell loss and increase muscle cell growth. Of the three, Fragment 176-191 (Frag 176-191) is considered to carry a lipolytic fragment. It appears to act on the beta-3 adrenergic receptors (ADRB3). This peptide has been suggested to lead to increased fat cell dissolution in fatty tissues and increased fat breakdown by triggering thermogenesis (heat production) in skeletal muscles by acting on these receptors.[2] Researchers have noticed that knock-out mice without ADRB3 receptors appear to not respond to the effects of Fragment 176-191.[3] Interestingly, researchers noticed that Frag 176-191 only appeared to lead to weight loss in obese mice and did not appear to affect lean mice. It was reported to lead to a nearly 50% reduction in weight gain in obese mice noticed over three weeks. Other elements of this blend, such as Mod GRF (1-29), have been studied in relation to improving body composition by increasing muscle cells. The apparent increase in muscle mass may be due to two mechanisms triggered by this peptide: muscle hypertrophy (increase in the size of muscle fibers) and muscle hyperplasia (increase in the number of muscle fibers).
FRAG 176-191 & MOD GRF 1-29 & IPAMORELIN AND BONE, JOINT FUNCTION
Researchers suggested that when the hGH Frag 176-191 was introduced in conjunction with hyaluronic acid in research models of osteoarthritis, it may potentiate joint cartilage growth. The study suggested that the peptide exposure in animal models of osteoarthritis appeared to improve joint cartilage.[4] Studies reported that the apparent improvement was more marked when used in combination with hyaluronic acid. Kwon et al. concluded that “Intra-articular AOD9604 injections using ultrasound guidance enhanced cartilage regeneration, and combined AOD9604 and HA … were more effective than HA or AOD9604 … alone in the collagenase-induced knee OA rabbit model.” In addition, peptides such as Mod GRF 1-29 and Ipamorelin have been suggested to improve bone function by activating bone cells via GH-mediated pathways. The use of these peptides may lead to increased activity, proliferation, and differentiation of bone-forming cells and may also lead to an increase in Bone Mineral Density (BMD).
FRAG 176-191 & MOD GRF 1-29 & IPAMORELIN AND CELL AGING
A blend of GH stimulating peptides, of which these three are classified, may stimulate the natural increase in GH levels. An increase in GH levels is associated with an improvement in cell proliferation due to telomere shortening and a reduction in cellular death due to a decline in processes such as oxidative stress.[5]
