Fragment 176-191 peptide (Frag 176-191) is a short segment of growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined from initial research on animal systems which suggested that Fragment 176-191 holds the potential to enhance fat metabolism in genetically engineered obese mice. Growth hormone (hGH) supplementation may supress carbohydrate metabolism, alter sensitivity towards insulin, promote long bone growth, and heighten insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that the synthetic fragment may enhance the lipolytic action of hGH without inducing ancillary impacts. The peptide is also available in 5mg.
OTHER KNOWN TITLES: Frag 176-191
MOLECULAR FORMULA: C78H125N23O23S2
MOLECULAR WEIGHT: 1817.1 g/mol
SEQUENCE: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
FRAGMENT 176-191 AND FAT CELLS
The fat cell dissolution potential of Fragment 176-191 stems from the peptide’s hypothetical potential to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the Fragment 176-191 peptide upon interaction with ADRB3 appeared to directly enhance fat burning in adipose tissue, and may also trigger skeletal muscle thermogenesisscle. Research indicates that genetically modified mice that lack ADRB3 may be resistant to the action of hGH / Fragment 176-191. One experimental study observed that exposure to Fragment 176-191 appeared to cause up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of exposure. The results suggest that there may be secondary pathways involved in energy homeostasis which may be capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.
FRAGMENT 176-191 AND HYPOGLYCEMIA
The C terminal end of hGH principally has been considered to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be an effective synthetic derivative of hGH in research on blood sugar control. The hypoglycemic potential is secondary to maintaining an increased expression of insulin in blood plasma.
FRAGMENT 176-191 AND CARTILAGE
Experimental research in Fragment 176-191 suggests its potential in cartilage regeneration. Researchers engaged in the study of synthetic peptides suggest that they may bring about cartilage regeneration through hyaluronic acid. Research in rabbits has observed that weekly exposure to Fragment 176-191 appeared to improve cartilage growth (within laboratory measures), and its co-introduction with hyaluronic acid (HA) appeared to be even more impactful.
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
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