PT-141, also known as bremelanotide, has been investigated in phase IIb human clinical trials to treat female hypoactive sexual desire disorder (HSDD). It was derived from a synthetic Melanocortin known as Melanotan 2 (MT-2). PT-141 is a Melanocortin that was developed to interact with Melanocortin-4 Receptor (MC-4R) and MC-1R. PT-141 has been studied for a variety of potential benefits, including implications in sexual dysfunction and cancer, and in aiding hemorrhages.
AKA: Bremelanotide
MOLECULAR FORMULA: C50H68N14O10
MOLECULAR WEIGHT: 1025.2 g/mol
SEQUENCE: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH
PUBCHEM: CID 9941379
CAS NUMBER: 189691-06-3
RECONSTITUTION: Required
PT-141 PEPTIDE (BREMELANOTIDE) AND SEXUAL AROUSAL
PT-141 appears to uniquely stimulate the MC-4R, which may trigger sexual arousal in the central nervous system and can affect sexual behavior.[1] The researchers report that “The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base.” Studies in mice agonist binding to MC-4R reported sexual arousal and enhanced copulation in both males and females.[2] The mechanism of PT-141 is different from medications like Viagra; it has the potential to treat both male and female sexual arousal disorders that are not caused by reduced blood flow to the genitals. One-third of men who suffered from erectile dysfunction (ED) but did not respond to sildenafil (Viagra) appeared to experience satisfactory erection for sexual intercourse using PT-141 (administered via nasal spray). The strong dose-dependent response in the trial indicated the effectiveness of PT-141 in some cases. Interestingly, it was removed from clinical trials for treating women with HSDD despite showing increased female sexual satisfaction and reducing female sexual distress scores without side effects.[3] Experts on female sexual dysfunction (FSD) consider a lack of established endpoints for trials of FSD and socio-cultural biases against women’s sexual health as the essential reasons for the non-approval of PT-141.[4] Researchers suggest the PT-141 treatment if combined with other existing modalities may enhance both physiological and psychological efficacies. In 2017, partly due to the outcry against the cessation of earlier trials, Phase II Reconnect trials were initiated for PT-141 for FSD, and research reporting is ongoing.
PT-141 PEPTIDE (BREMELANOTIDE) AND INFECTION
The MC-1R appears to mediate important anti-fungal and anti-inflammatory effects in a rat model of specific fungal infection.[5] This may be relevant to PT-141 peptides as current medications have limited mechanisms of action and show adverse effects in some patients. The alternative therapy might control morbidity and mortality, especially in immunocompromised patients.
PT-141 PEPTIDE (BREMELANOTIDE) AND HEMORRHAGE
In 2009, modified PT-141 was investigated for use in hemorrhagic shock. The peptide appears to control ischemia and protect tissues against inadequate blood supply hypovolemic (hemorrhagic) shock through interaction with both MC-1R and MC-4R. It was observed in phase IIb trials that the administration of the peptide exhibited no side effects. The modified version is referred to as PL-6983.
PT-141 PEPTIDE (BREMELANOTIDE) AND CANCER
The MC-1R receptor may be an important stimulus of DNA repair pathways, and is of relevance in cancer research and prevention.[6] The scientists reported that “MC1R signalling activates antioxidant, DNA repair and survival pathways.” People with variants of MC-1R appear to be more prone to both basal cell and squamous cell carcinoma.[7] Altered PT-141 may be used to bind to these variants and prevent or treat these cancers.
Right now, PT-141 is well known for its potential in sexual dysfunction research. There is potential to expand its research in other diseases. For instance, a mutant or deleted MC-4R may trigger some instances of obesity and influence about 6% of early-onset obesity cases. PT-141 may help to study this specific reason for obesity and illustrate a pathway for intervention. MC-1R has also been associated with pain, inflammation, kidney pathology, and the spread of infection; the peptide may help investigate diverse research domains. Experimental research in PT-141 reports the peptides appears to exhibit minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage (per kg) in mice does not match humans.
Our Advantage:
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service:
1)International Authorized Third-Party Test For The Products You Demand.
2)60 Days Warranty of quality of goods.
Packing & Shipping:
1.As your requirements.
2. Prompt shipment after receipt of your order confirmation.
3.Transit could be DHL UPS TNT EMS Fedex and so on.
4. For mass orders,it will be delivered by air or sea.
5.Depending on your locationplease allow 1-5 business days for your order to arrive.
6.For small order please expect 3-7 days by UPS DHL EMS
7.For mass order please allow 5-8 days by air 15-30 days by sea.
Whatever you're looking for, we've got it!"Ready to explore further?
Inquiry directly for more details
About us
WuhanZhengtai Technology Co., Ltd is mainly engaged in the export of fine chemicals, cosmetic raw materials, food additives, pharmaceutical intermediates and other products; Our company is committed to the development of international market, our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
Meanwhile, we possess of complete Q. A. And Q. C. System, supply chemical products with good quality and custom-tailored products according to our clients′ requirement. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the 15 years. With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
Our advantages
Quality: Purity above 99%, directly produced by the manufacturer, can accept quality testing, and can also customize any content of powder, liquid, oil, etc.
Transport: We can accept sea freight, air freight, and express delivery, with a guarantee time of 1-2 weeks and a customs clearance rate of over 99%.
Service: In addition to powder, we also have liquids, water-based agents, oils, tablets, and professional customized synthesis routes. We provide you with professional guidance on product use, product synthesis, and product customization.
Price: We do not engage in price wars. We are manufacturer and can provide high quality products with factory price.
RFQ
Q: How to start orders or make payments?
A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How to confirm the Product Quality before placing orders?
A:You can get samples for some products to test. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q: What's your MOQ?
A:For the high value product, our MOQ starts from 1box.
Q: Is there a discount?
A: Yes, for larger quantity, we always support with better price.
Q:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q:How to contact us ?
You can choose your interested products and send inquiry to us.
You can dial our telephone directly.
