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Jan.2024 10
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Tirzepatide 5mg CAS 2023788-19-2
Introduction
Tirzepatide is a GIP receptor and GLP-1 receptor agonist, leading to significantly improved glycemic control in type 2 diabetics and significant weight reduction.
Details

The FDA approved Tirzepatide in May 2022. Tirzepatide can also be used off-label for treating obesity. It is currently implemented as a second-line diabetes medication, similar to GLP-1 medications like semaglutide.It is a once-a-week subcutaneous injectable medication with incremental dose increases. 

Current clinical data has demonstrated that tirzepatide is superior to placebo in improving hemoglobin A1C levels. The SURPASS-5 clinical trial showed a -2.11% reduction in hemoglobin A1C levels at 5mg per week dosing, compared to -0.86% with placebo. At the highest dose of 15 mg per week, tirzepatide led to a -2.34% reduction in hemoglobin A1C. This was demonstrated over 40 weeks. A weight reduction of 5.4 kg was seen with 5mg of tirzepatide dosing, and a 10.5 kg reduction was seen with 15 mg dosing. This dose-dependent correlation with weight loss is similar to semaglutide, a common GLP-1 medication utilized for weight loss management.

How does Tirzepatide work?

Tirzepatide is a novel first-in-class drug that is used to treat type 2 diabetes and licensed in the US. The tirzepatide drug is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. GIP and GLP-1 are hormones called incretins that are released by the intestines.

Both GIP and GLP-1 increase the production of insulin, with GLP-1 promoting a feeling of fullness and delaying stomach emptying and controlling appetite.

GIP has an effect to reduce fat accumulation, increases bone formation, increases glucagon production, and reduces acid secretion in the stomach.

The combination of GIP and GLP-1 agonists makes tirzepatide a unqiue and very effective medication.

The medication is administered as a once weekly subcutaneous injection into the midriff, upper arm or thigh.

The medication is titrated on a 5mg, 10mg and 15mg dosage dependant on blood sugar and the propensity for side effects from a patient.

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